Microbes: What they do, how
antibiotics change them

Easir Abedin

Microorganisms - bacteria, archaea, fungi, algae, viruses and protists - are often easy to overlook. For the most part (except fungal fruiting bodies seen as mushrooms) we can't see microbes. The effects of microbes we feel are usually associated with an illness. Most people know that bacteria and viruses can act as "germs" and cause disease. Because of this it seems perfectly acceptable to try to wipe all of the germs out of our environment by using antibacterial agents (found in everything from hand soap to sweat socks) and antibiotics. However, our use of antibiotics and antibacterial agents is changing the microbes in our environment, making the germs tougher to beat and eliminating some beneficial microbes.
   Beneficial functions of microorganisms
   Microorganisms are essential to our very existence. They are ubiquitous, found in common environments such as soil, water, and air as well as exotic locales as diverse as deep sea hydrothermal vents and soda lime lakes. In these natural environments microorganisms have very specific jobs. They are responsible for recycling nutrients in our soil and purifying our water. We also use microorganisms in constructed environments to serve our own functions.
   *Nutrient Recycling. When plants and animals take up nutrients, they are not available to other living organisms. When the plants and animals die, the nutrients remain in the carcass. If the dead material, or detritus, is not broken down by microbes, those nutrients will never become available to help sustain the life of other organisms. There are a finite amount of nutrients available in the environment and we cannot simply make more. The nutrients that are trapped in detritus must be released in order for life to continue. It is the microbial population of the environment that is responsible for this nutrient recycling.
   We depend on having a microbial population, called our microbiota, for our health. There are normally 10 times more microbial cells in a human body than human cells. The good bacteria that live on and in us protect us from the bad invaders that might come our way. Without the good bacteria, the bad ones can slip in and easily cause us problems. Our own digestion has also evolved to use bacteria for assistance, allowing us to gain nutrition from plant polysaccharides that our own enzymes will not degrade. This is one of the reasons why taking antibiotics can lead to episodes of diarrhea - we have disrupted our natural gut biota.
   Microbes have been used for centuries to provide us with food. Bread is the result of a microbial fermentation of sugars to produce carbon dioxide - the bubbles that make bread rise. We owe our beer and wine to similar little yeast that convert sugars into alcohol for our consumption. Yogurt and cheese are produced by bacterial fermentation of lactose, the sugar in milk. Microbes such as phytoplankton also serve as the nutrient source that indirectly feeds all marine animals. And microbial symbioses with plants allow them to grow strong and increase productivity - sometimes they are even essential for plant survival.
   Microorganisms are responsible for getting rid the waste generated by industry and households. They detoxify acid mine drainage and other toxins that we dump into the soil and water. The nutrients gained from the breakdown of these products then go to feed plants or algae, which in turn feed all animals.
   *Waste Water Treatment. When we flush things down the drain or the toilet, they go to a septic system or waste water treatment plant at the end of the line. After primary mechanical treatment and aeration microbes remove organic materials from the filthy waters that flow into these systems and, eventually, water can safely be returned to the rivers and streams. The methane produced during treatment can even be used to generate heat or electricity for the operation!
   We have discovered that microorganisms are useful for making things as well. Products such as xanthan gum (a food thickener) are harvested from their bacterial producers. Most of our vitamin B12, riboflavin, and vitamin C are produced by bacterial fermentation. Approximately 70% of antibiotics currently in use are also the product of microbial fermentation.
   Sources of antibiotics in the environment
   In spite of all of the benefits of having a healthy microbial population, antibiotics and antibacterial agents are added to the environment at a rate of over a million pounds per week. There are several routes of entry of antimicrobial agents into the environment. Studies have shown that introduction by these routes has changed the antibiotic susceptibility of the microbes in those environments and/or changed the predominant microbes.
   Sewage. The antibiotics that we take in are not all processed by our bodies. Some of them are expelled as waste and wind up in our waste water treatment plants. Of bacteria isolated from sludge remaining after wastewater treatment at one plant, 46.4% were resistant to multiple antibiotics. Sewage from hospitals and pharmaceutical plants has been shown to contribute to antibiotic resistance in treatment plants. Rivers contaminated with urban effluent and agricultural runoff have also been shown to have greater antibiotic resistant bacterial populations than areas upstream of the contamination source. Antibiotic resistance in streams is also indirectly selected for by an increase in industrial wastes containing heavy metals.
   Medical waste. The dispensing of antibiotics in a medical facility inevitably leads to waste. Discharge from hospitals has been shown to cause an increase in bacterial populations resistant to certain antibiotics such as oxytetracycline.
   Antibiotic sales total more than $8 billion worldwide each year. That is 50 million pounds produced each year, 25 million pounds of which are prescribed for human use. Discharge of wastewater from pharmaceutical plant has been associated with an increase in the prevalence of single- and multiple-antibiotic resistance in indicator organisms.
   Household products. Over 700 "antibacterial" household products have been introduced in the past five years. These include such items as sweat socks, toothpastes, kitchen plastics, cement and paints. The more common antibacterial ingredients in these formulations are triclosan, quartenary ammonium compounds, alcohol, and bleach. Microbes resistant to each of these compounds have been documented in nature and in some human pathogens. These products wind up in the sewage or landfill after being used in our households.
   About 300,000 pounds of antibiotics are used in plant production each year. They are sprayed on high-value crops such as fruit trees to prevent bacterial infections. This can select for resistant bacteria on our crops. Not all of the spray remains on the fruit. Most of the antibiotics are washed into the soil and eventually end up in the ground water.
   Animal production. Antibiotics are commonly added at subtherapeutic levels to animal feeds as growth promoters. They are also added to fishery waters. About 24 million pounds of antibiotics are fed to animals every year. Due to this practice antibiotic resistance in foods has become a health concern. Bacteria such as drug resistant Salmonella typhimurium, Escherichia coli and Enterococcus have increased clinically as animal antibiotic use has risen. It is also possible that our normal gut microbiota have gained antibiotic resistance from antibiotic-exposed food animals. A popular theory is that vancomycin resistant strains of the bacterium Enterococcus (VRE), a major cause of postsurgical infections, have arisen in Europe due to the use of the antibiotic avoparcin as an animal growth promoter. At least one study, however, shows that in minced beef and pork, VRE occurs very rarely. The use of oxytetracycline in aquaculture has been shown to cause a seasonal shift in bacterial species towards Enterobacteriaceae and is associated with increased antibiotic resistance.
   Antibiotics do not, in themselves, cause resistance. Instead, they allow naturally resistant variants within a population to survive and reproduce while those individuals without the resistance factor die. Once in a bacterial population, antibiotic resistance can spread rapidly. Even unrelated bacteria can gain resistance from their neighbors in a phenomenon called horizontal gene transfer. Resistance to antibiotics is encoded in DNA, the genetic blueprint for life. Bacteria are able to exchange DNA, especially in the form of plasmids (small, self-replicating circles of DNA) and pass resistance very rapidly.
   Curbing spread of antibiotic resistance
   Antibiotic resistance is inevitable. However, there are a few things that we, as consumers, can do to control the spread of antibiotic resistance.
   Do not seek antibiotics for the treatment of viral infections such as the common cold, sore throat, bronchitis, or flu. Antibiotics have no effect on viral diseases. Taking antibiotics improperly simply leads to more antibiotics in the sewage and a buildup of antibiotic resistant bacteria in your microbiota.
   Take the full course of antibiotics when they are prescribed. Stopping when you feel better means that some bacteria in your body were exposed to only small doses of the antibiotic and have survived. They are now resistant to small amounts of the antibiotic. The next time you get an infection they will not be so easily killed.
   Avoid unnecessary antibacterial household products. We need the bacteria that surround us, and it is possible that trying to kill them is causing harm. By introducing antibacterial products into the landfills and sewage we are ensuring that only the microbes that are resistant to these products survive. Research is underway to determine if we are selecting for resistant bacterial populations causing antibacterial agents, like antibiotics, to lose their effectiveness or disrupt the effectiveness of the wastewater treatment plants or nutrient cycling in the soil. Use antibacterial hand soaps only when dealing with ill and immunocompromised individuals.
   Wash your hands. The best way to stop the spread of any bacterial infection is through simple hygiene measures. Washing hands in warm soapy water for at least 20 seconds is enough to eliminate most of the potential pathogens. Also be sure to wash all fruits and vegetables well before eating them.

^ TOP OF THIS PAGE ^ MAIN PAGE

Obama McCain

Rayyan Kamal

I, like most people in my demographic, am a Barack Obama supporter. I'll admit that I haven't conducted an exhaustive examination of the presidential candidates' policies on issues relevant to me i.e. foreign policy. In fact, apart from being vaguely aware of the fact that Obama is for more government while McCain is for less, I can't say I know much more. But I am willing to bet that a lot more Americans my age are in my position than you might think. (And they're actually eligible to vote, so they have no excuse!) I have met several Obama supporters who are so convinced that only he can "save" America that they would be willing to give their lives for him. But ask them to cut the idealistic, abstract language and talk about issues and they'll become silent.
   In any case, I only wish Obama had as much support throughout the US as he does in Yale. In a poll conducted recently by the Yale Daily News, it was found that 81 percent of the Yale undergraduate student body plans to vote for Obama this coming Tuesday or have already mailed in absentee ballots for him. Only 12 percent of students said they are voting Republican. In the most recent Washington Post-ABC News tracking poll, it was found that 52 percent of people planning to vote would cast their ballot for Obama whereas 45 percent said they would back McCain. This statistic makes me disagree with another result of the Yale poll: 81 percent of respondents said they think Obama and Biden will win on Election Day, compared with a mere 4 percent who believe McCain and Palin will emerge victorious. This feels like complacency and overconfidence on the part of Yalies, probably a result of interacting with a disproportionately high number of Democrats on campus.
   A lot of Obama supporters are worried that national polls overestimate the number of votes Obama will receive due to hidden racism. There might be many voters who secretly refuse to vote for a black man but hide this sentiment in public and, perhaps because they are Democrats, pretend that they will vote for Obama when asked. By the same token, McCain supporters worry that many closeted Obama supporters who live in highly Republican areas and have so far pretended to be McCain supporters will go Democrat when they are alone in the voting booth.
   In my opinion, one of the few things that McCain has going for him is that he has an adopted Bangladeshi daughter. But as heartwarming as it would be to have a Bangladeshi living in the White House, I doubt it will have any impact on McCain's stance towards Bangladesh. After all, it was his wife who adopted the girl without first consulting him. In addition, I think it's telling that I've rarely seen McCain's adopted daughter as part of his campaign, whereas his biological children have been much more visible, accompanying him to more events. I know some people who would disagree with me and say that McCain would, indeed, adopt a more favourable position on Bangladesh than Obama.
   I just hope we won't have to find out.
   Rayyan Kamal is a senior
   at Yale University.

^ TOP OF THIS PAGE ^ MAIN PAGE

Shipbuilding industry needs the government support

Holiday Report

Like many other Asian countries, Bangladesh's shipbuilding industry need support from the government to attain competitiveness and capture the world market. said K.M. Mahmood Ur Rahman, chairman, High Speed Group of companies at it's 47th anniversary programme last week.
   Held at the High Speed Shipyard premises, the function was addressed by Dr. Hossain Zillur Rahman, adviser for the ministries of education and commerce. He said that the government was trying its best to support this prospective industry. The government has already met their bonded facilities demand to continue a hassle free import of exportable materials and equipments he said adding that the demand from the shipbuilding association president as exofficio director in the FBCCI would be given due consideration.
   High Speed started its operation in the water transport sector from 1961 and so far has build a large fleet of deep sea fishing trawlers, cargo vessels, passenger ferry and launches suitable for plying along the inland waterways. It has also built world class ships for many overseas organizations and companies.
   The company has successfully completed some big infrastructure projects including Petro Chemical Industries, Hydro Power Plant and the first Burge Mounted Power Station in Bangladesh. The 4- year-old company achieved excellence by building a good number of high steel structural engineering like gas pipe lines, pressure vessels, installation of heavy machinery and equipments, civil construction, storage tanks of Zia Fertilizer, Jamuna Fertilizer, KAFCO, Chittagong Hydro power, Parbatipur Railway workshops and many other projects.
   Mahmood Ur Rahman who is also president of three other trade associations in the water transport sector (launch owner association, Bangladesh shipbuilders association and Bangladesh cargo owners associations) said, the company has now undertaken an expansion plan to construct and export foreign vessels as several enquiries are received by them almost everyday from Europe and Middle East.
   But due to lack of proper support from the government, the sector can not perform its best as bankers are yet to show sufficinet interest to finance the shipbuilding business.
   Among others present at the company's anniversary programme included, professor Khabirul Haque Chowdhury of Naval Architecture department, BUET, captain AKM Shafiqullah, director general of the Department of Shipping leading business personalities of the country.

^ TOP OF THIS PAGE ^ MAIN PAGE